The science behind our platform
Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy
Jean Pierre Bikorimana, Roudy Farah, Jamilah Abusarah, Gabrielle Arona Mandl, Mohamed Ali Erregragui, Marina Pereira Gonçalves, Sebastien Talbot, Perla Matar, Malak Lahrichi, Nehme El-Hachem, and Moutih Rafei.
–iScience –2025
ARM‑X: an adaptable mesenchymal stromal cell‑based vaccination platform suitable for solid tumors
Jean Pierre Bikorimana, Nehme El‑Hachem, Gabrielle A. Mandl, Daniela Stanga, Jamilah Abusarah, Roudy Farah, Marina P. Gonçalves, Perla Matar, Malak Lahrichi, Sebastien Talbot and Moutih Rafei.
–Stem Cell Research & Therapy–2025
Mesenchymal stromal cells 2.0: thinking outside the box
Gabrielle A. Mandl, Malak Lahrichi, Perla Matar, Jamilah Abusarah, Roudy Farah, Jean Pierre Bikorimana, Abba Cisse and Moutih Rafei.
–Frontiers in Immunology–2025
A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses
Marina Pereira Gonçalves, Roudy Farah, Jean-Pierre Bikorimana, Jamilah Abusarah, Nehme EL-Hachem, Wael Saad, Sebastien Talbot, Daniela Stanga, Simon Beaudoin, Sebastien Plouffe, and Moutih Rafei.
–iScience–2024
UM171A‑induced ROS promote antigen cross‑presentation of immunogenic peptides by bone marrow‑derived mesenchymal stromal cells
Natasha Salame, Jean‑Pierre Bikorimana, Nehme El‑Hachem, Wael Saad, Mazen Kurdi, Jing Zhao, Nicoletta Eliopoulos, Riam Shammaa, and Moutih Rafei.
–Stem Cell Research & Therapy –2022
The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasomereprogrammed
mesenchymal stromal cells
Jean-Pierre Bikorimana, Nehme El- Hachem, Jamilah Abusarah, Nicoletta Eliopoulos, Sebastien Talbot, Riam Shammaa, Moutih Rafei.
–iScience–2022
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, …, Abed-El-Hakim El-Kadiry, Riam Shammaa, Moutih Rafei.
–Cell Reports Medicine–2021
Thymoproteasome-Expressing
Mesenchymal Stromal Cells Confer
Protective Anti-Tumor Immunity via
Cross-Priming of Endogenous
Dendritic Cells
Jean-Pierre Bikorimana, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Jamilah Abusarah, Natasha Salame, Riam Shammaa and Moutih Rafei.
–Frontiers in Immunology–2020
